Live Cell Image Analysis

This project is part of the ITC2 research project of the NBIP and focuses on the development of a novel automated monitoring system for live cell imaging based on real time evaluation. Our scope is to develop a robust real-time image analysis and modelling solution along with its associated development environment. Both the algorithms and associated software will be made available to all NBIP partners via a software workbench. The ITC2 project partners research programmes in the following cores of the NBIP: Molecular and Cellular Imaging Core (RCSI), Compute Node (UCC) and elements within the Imaging Technology Core (RCSI, NUIM).

Contact person: Dr Perrine Paul

Collaborator(s): Dr Heinrich Huber (RCSI/Siemens Ireland)

Systems Analysis of Caspase Activation Models

Apoptosis is a form of programmed cell death, removing unwanted cells within multicellular organisms to maintain a proper balance between cell reproduction and death. This project uses engineering methods from Systems and Control Theory to analyse different robustness aspects for models of the direct signal transduction pathway of receptor-induced apoptosis. It is a collaborative research with the Department of Physiology and Medical Physics at RCSI.

Contact person: Dr Eric Bullinger

Collaborator(s): Dr Markus Rehm (RCSI), Dr Heinrich Huber (RCSI/SIEMENS Ireland)

Mathematical Modelling of the Mechanisms of Cell Death

This project compares apoptotic and alternative cell death signalling pathways by comprehensive systems modelling. It aims at identifying the molecular control mechanisms regulating cell death and survival in human cancer cells. Furthermore, it will provide experimentally testable hypotheses on the protein dynamics of the intracellular signalling networks. This project is carried out in collaboration with Dr. Markus Rehm at the Department of Physiology and Medical Physics, RCSI.

Contact person: Dr Dimitris Kalamatianos

Collaborator(s): Dr Markus Rehm (RCSI)