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Systems Biology @ Hamilton Institute ::: Publications
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Selected recent publications

Reports

Selected recent publications

For full listings see individual websites.

[26] P. Wellstead. Systems Biology and the Spirit of Tustin. IEEE Control Systems Magazine, February, 2010.
[25] P. Wellstead. On the Industrialization of Biology. AI & Society, 2009. [ DOI ]
[24] M. Cloutier and P. Wellstead. The control systems structures of energy metabolism. Royal Society Interface Journal, 2009. [ DOI ]
[23] M. Verwoerd and O. Mason. On computing the critical coupling coefficient for the kuramoto model on a complete bipartite graph. SIAM Journal of Applied Dynamics, 8(1):417-453, 2009. [ bib ]
[22] M. Cloutier, Pierre O. Poliquin, Mario Jolicoeur, and P. Wellstead. An integrative modelling approach for the implications of energy metabolism in neurodegeneration. In Foundations of Systems Biology in Engineering (FOSBE), Denver, USA, to appear, 2009. [ bib ]
[21] B.-F. Krippendorff, D. A. Oyarzún, and W. Huisinga. Ligand accumulation counteracts therapeutic inhibition of receptor systems. In Proceedings of the 3rd Foundations of Systems Biology and Engineering (FOSBE), Denver, USA, 2009. [ bib ]
[20] D. A. Oyarzún, Brian P. Ingalls, R. H. Middleton, and D. Kalamatianos. Sequential activation of metabolic pathways: a dynamic optimization approach. Bulletin of Mathematical Biology, 2009. [ bib | DOI ]
[19] M. Cloutier, Fiachra B. Bolger, John P. Lowry, and P. Wellstead. An integrative dynamic model of brain energy metabolism using in vivo neurochemical measurements. Journal of Computational Neuroscience, 2009. [ bib | DOI ]
[18] P. Wellstead, E. Bullinger, D. Kalamatianos, O. Mason, and M. Verwoerd. The role of control and system theory in systems biology. Annual Reviews in Control, 32:33-47, 2008. [ bib ]
[17] S. N. Sreenath, K.-H. Cho, and P. Wellstead. Modelling the dynamics of signalling pathways., volume 357 of Essays in Biochemistry: Systems Biology, Lecture Notes in Control and Information Sciences, pages 1-15. Portland Press, 2008. [ bib ]
[16] T. Rutjes, O. Mason, and M. Verwoerd. On the growth of the largest component in duplication-divergence models of protein interaction networks. In Foundations of Systems Biology in Engineering (FOSBE), Stuttgart, Germany, 2007. [ bib ]
[15] M. Verwoerd and O. Mason. Global phase-locking in finite populations of phase-coupled oscillators. to appear in Siam Journal of Applied Dynamical Systems, 2007. [ bib | http ]
[14] E. Bullinger, R. Findeisen, D. Kalamatianos, , and P. Wellstead. System and control theory furthers the understanding of biological signal transduction. In I. Queinnec, S. Tarbouriech, G. Garcia, and S.-I. Niculescu, editors, Biology and control theory: current challenges, volume 357 of Lecture Notes in Control and Information Sciences. Springer-Verlag, Berlin, Germany, 2007. [ bib ]
[13] J. Vera, E. Balsa-Canto, P. Wellstead, J.R. Banga, and O. Wolkenhauer. Power-law models of signal transduction pathways. Cellular Signalling, 19:1531-1541, 2007. [ bib | http ]
[12] T. Eißing, S. Waldherr, F. Allgöwer, P. Scheurich, and E. Bullinger. Response to bistability in apoptosis: Roles of Bax, Bcl-2, and mitochondrial permeability transition pores. Biophys. J., 2007. In press. [ bib | http ]
[11] T. Eißing, S. Waldherr, F. Allgöwer, P. Scheurich, and E. Bullinger. Steady state and (bi-)stability evaluation of simple protease signalling networks. BioSystems, 2007. In press. [ bib | http ]
[10] T. Jahnke and W. Huisinga. Solving the chemical master equation for monomolecular reaction systems analytically. J. Math. Biol., 54:1-26, 2007. [ bib | .pdf ]
[9] O. Mason and M.H.A. Verwoerd. Graph theory and networks in biology. IET Systems Biology, 1(2):89-119, 2007. [ bib ]
[8] W. Huisinga and B. Schmidt. Metastability and dominant eigenvalues of transfer operators. In Benedict Leimkuhler et al., editor, Advances in Algorithms for Macromolecular Simulation, volume 49 of Lecture Notes in Computational Science and Engineering, pages 167-182. Springer, 2006. [ bib | .pdf ]
[7] W. Huisinga, R. Telgmann, and M. Wulkow. The virtual lab approach to pharmacokinetic: Design principles and concepts. Drug Discovery Today, 11(17 & 18):800-805, 2006. [ bib | .pdf ]
[6] B.F. Krippendorff, P. Lienau, A. Reichel, and W. Huisinga. Optimizing classification of drug-drug interaction potential for CYP450 iso-enzymes inhibition assays in early drug discovery. J. Biomolecular Screening, 2006. in press, online Nov 27. [ bib | .pdf ]
[5] O. Wolkenhauer, M. Mesarovic, and P. Wellstead. A plea for more theory in molecular biology. In E. Butcher, P. Bringmann, and B. Weiss, editors, Systems Biology - Applications and Perspectives. Springer Verlag, Berlin, 2006. [ bib ]
[4] T. Millat, E. Bullinger, J. Rohwer, and O. Wolkenhauer. Approximations and their consequences for dynamic modelling of signal transduction pathways. Math Bioscience, 2006. In press. [ bib | http ]
[3] M. Nickel, E. Bullinger, and F. Beckmann. Functional morphology of Tethya species (porifera): 2. three-dimensional morphometrics on spicules and skeleton superstructures of T. minuta. Zoomorphology, 125(4):225-239, 2006. [ bib | http ]
[2] K-H. Cho, S-M. Choo, P. Wellstead, and O. Wolkenhauer. A unified framework for unravelling the functional interaction structure of a biomolecular network based on stimulus-response experiment data. FEBS Letters, 579(20):4520-4528, 2005. [ bib ]
[1] O. Wolkenhauer, S. N. Sreenath, P. Wellstead, M. Ullar, and K-H. Cho. A systems and signal-oriented approach to intracellular dynamics. Biochemical Society Trans., 33(3):505-515, 2005. [ bib ]
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Reports

Printed copies of the annual reports and general reports are available by emailing your request to rosemary.hunt@nuim.ie.

P. Wellstead: Annual report 2008-2009: 5 February, 2009 (PDF, 92 MBytes)
P. Wellstead: Annual report 2007-2008: 15 January, 2009 (PDF, 90 MBytes)
P. Wellstead: Annual report 2006-2007: 5 December, 2007 (PDF, 1.4 MBytes)
P. Wellstead: Annual report 2005-2006: 6 December, 2006 (PDF, 12.8 MBytes)
P. Wellstead: Annual report 2004-2005 (PDF 582 kBytes)
P. Wellstead, M. Cloutier: "A Systems Apporach to Parkinson's Disease". (PDF, 1.5 MBytes)
P. Wellstead: "Systems Biology and the Spirit of Tustin". The Tustin Lecture, Prof. Peter Wellstead, May 1st, The Savoy Place, London. (PDF, 665 kBytes)
P. Wellstead: The Rôle of Control and Systems Theory in Systems Biology. Edited text of a Plenary Lecture to be presented at the 10th IFAC International Symposium on Computer Applications in Biotechnology and the 8th IFAC International Symposium on Dynamics and the Control of Process Systems, June 2007. (PDF, 224 kBytes)
P. Wellstead: Schrödinger's legacy: Systems and life. An E.T.S. Walton Lecture given as part of the W.R. Hamilton Bi-Centenary Lecture Series. The Royal Irish Academy, 21st April, 2005. Updated manuscript: 16 June 2006.
(PDF, 175 kBytes) (Video)
P. Wellstead: On the industrialisation of biology. Technical report, A `Catedra Amundson' Lecture. University of Guadalajara, 26th September, 2006. (PDF, 164.8 kBytes)
Peter Wellstead, Rick Middleton and Olaf Wolkenhauer:
Feedback Medicine, Working Notes on Control Systems Concepts in Personalised, Predictive Medicine and Combinatorial Intervention (2006) (PDF, 319 kBytes)
Oliver Mason and Mark Verwoerd: Graph Theory and Networks in Biology (2006) (PDF, 394 kBytes)
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