Publications 

Links: Hamilton Institute Thesis Archive

Year Authors Title
  2009 M. von Kleist and W. Huisinga Pharmacokinetic-Pharmacodynamic relationship of NRTIs and its connection to viral escape: An example based on Zidovudine Eur J Pharm Sci., 36, pp532-543. DOI: doi:10.1016/j.ejps.2008.12.010 [bibtex]
  2009 Ben-Fillippo Krippendorff, Diego Oyarzun and Wilhelm Huisinga Ligand accumulation counteracts therapeutic inhibition of receptor systems Foundations of Systems Biology & Engineering 2009, Denver, USA., pp173-176 [bibtex]
  2009 BF Krippendorff, R Neuhaus, P Lienau, A Reichel, W Huisinga Mechanism-Based Inhibition: Deriving KI and kinact Directly from Time-Dependent IC50 Values Journal of Biomolecular Screening, 14, pp913-923. DOI: 10.1177/1087057109336751 [bibtex]
  2009 B.-F. Krippendorff, K. K├╝ster, C. Kloft, W. Huisinga Nonlinear Pharmacokinetics of Therapeutic Proteins Resulting from Receptor Mediated Endocytosis J. Pharmacokinet. Pharmacodyn., 36, pp239-260. DOI: 10.1007/s10928-009-9120-1 [bibtex]
  2008 T. Jahnke, and W. Huisinga A dynamical low-rank approach to the chemical master equation Bull. Math. Biol., 70, pp2283-2302 [bibtex]
  2008 P. Deuflhard, W. Huisinga, T. Jahnke, and M. Wulkow Adaptive discrete Galerkin methods applied to the chemical master equation SIAM J. Sci. Comput., 30, pp2990-3011 [bibtex]
  2007 T. Jahnke, and W. Huisinga Solving the chemical master equation for monomolecular reaction systems analytically J. Math. Biol. , 54, pp1-26 [bibtex]
  2007 S. Ruumldiger, J.W. Shuai, W. Huisinga, Ch. Nagaiah, G. Warnecke, I. Parker, M. Falcke Hybrid stochastic and deterministic simulations of calcium blips Biophysical Journal, 93, pp1847-1857 [bibtex]
  2007 M. von Kleist, C. Koft, and W. Huisinga Combining Systems Biology with Physiologically based Pharmacokinetics to Support the Understanding of Drug Effects Proceeding Fosbe 2007, pp. 231-236 [bibtex]
  2007 M. von Kleist and W. Huisinga Physiologically based pharmacokinetic modelling: a sub-compartmentalized model of tissue distribution J Pharmacokinet Pharmacodyn, 34, pp789-806 [bibtex]
  2007 B.-F. Krippendorff, P. Lienau, A. Reichel, W. Huisinga Optimizing Classification of Drug-Drug Interaction Potential for CYP450 Isoenzyme Inhibition Assays in Early Drug Discovery J Biomol Screen, 12, pp92-99 [bibtex]
  2006 W. Huisinga Computational Physiology European Communications in Mathematical and Theoretical Biology, 8, pp12-13 [bibtex]
  2006 W. Huisinga, R. Telgmann, and M. Wulkow The virtual lab approach to pharmacokinetic: Design principles and concepts. Drug Discovery Today, 11, pp800-805 [bibtex]
  2006 R. Telgmann, M. von Kleist, and W. Huisinga Software Supported Modelling in Pharmacokinetics Computational Life Sciences II, Lecture Notes in Computer Science 4216 (2006), M.R. Berthold, R. Glen, and I. Fischer (Eds.), Springer, pp. 216-225 [bibtex]
  2006 A. Weise, I. Horenko, and W. Huisinga Adaptive Approach for Modelling Variability in Pharmacokinetics In: Computational Life Sciences II, Lecture Notes in Computer Science 4216 (2006), M.R. Berthold, R. Glen, and I. Fischer (Eds.), Springer, pp. 194-204 [bibtex]
  2005 W. Huisinga and B. Schmidt Metastability and Dominant Eigenvalues of Transfer Operators In: Advances in Algorithms for Macromolecular Simulation [bibtex]
  2005 K. Abraham, H. Mielke, W. Huisinga and U. Gundert-Remy Elevated Internal Exposure of Children in Simulated Acute Inhalation of Volatile Organic Compounds: Effects of Concentration and Duration Arch Toxicol, 79, pp63-73 [bibtex]
  2005 K. Abraham, H. Mielke, W. Huisinga and U. Gundert-Remy Elevated Internal Exposure of Children in Simulated Acute Inhalation of Volatile Organic Compounds: Dependency on Properties of the Chemical Basic and Clinical Pharmacology and Toxicology, 96, pp242-243 [bibtex]
  2005 I. Horenko, S. Lorenz, C. Schutte and W. Huisinga Adaptive Approach for Non-Linear Sensitivity Analysis of Reaction Kinetics J. Comp. Chem., 26, pp941-948 [bibtex]
  2005 A. Alfonsi, E. Cances, G. Turinici, B. Di Ventura and W. Huisinga Adaptive simulation of hybrid stochastic and deterministic models for biochemical systems ESAIM: Proceedings, 14, pp1-13 [bibtex]

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